Kusuhara H and Sugiyama Y Active efflux across the blood-brain barrier: Presentations referencing similar topics. These, together with the autoregulation process, allow the brain to control the cerebral blood perfusion [ ]. Dolutegravir DTG , a newer integrase strand transfer inhibitor, is not yet available in sub-Saharan Africa but has the potential to gain attention in this region in the next few years due to its attractive safety, efficacy, and resistance profile. These data support the conclusion that one should avoid developing good P-gp substrates as CNS drugs. Biopharm Drug Dispos
Demystifying brain penetration in central nervous system drug discovery. Miniperspective.
Despite optimal responses to combination antiretroviral therapy cART , HIV-infected children continue to show neurocognitive deficits with macro- and microstructural brain injury and signs of neuroinflammation. Furthermore, a high mutation rate of the viral genome and its ability to undergo latency for extended periods by integrating into the host genome make curing HIV-1 a daunting task. Importantly, several drug interactions that may facilitate CNS penetration of antiretrovirals occur via inhibition of the efflux transporters that are involved in limiting brain penetration of drugs. Partial atomic charges were calculated using the AM1 semiempirical method, also implemented by the HyperChem 7. Histamine Receptor Knockout Mice.
How it Works: Predicting Central Nervous System (CNS) Drug Penetration | Lab Manager
Indinavir and efavirenz are the only antiretroviral drugs for which CNS area under the concentration-time curves using unbound plasma and CSF concentrations has been calculated. We do not retain these email addresses. Because cyclosporine A is the most potent P-gp inhibitor on the market, this study suggests that the risk of DDI due to P-gp inhibition is low unless the P-gp inhibition activity of the drug in question is much greater than cyclosporine A. A recent work Zhang et al. Cl bulk can play an important role in decreasing K p, free for low permeability compounds.
The distribution of many drugs to the brain is significantly different from that occurring in other organs, owing to the presence of the blood-brain barrier BBB. Browse by related subjects Browse by related subjects. Table 2 shows the wide variability in poor metabolizer frequencies in different African populations as reported in different studies. A new computer program for QSAR analysis. Computational models to predict blood-brain barrier permeation and CNS activity.